Therapeutic Potential of Terpene Nanoemulsions in Targeting Breast Cancer: A MultiModel Approach Toward Therapeutic Strategies

Abstract

The characteristics of phytocompounds have undergone extensive 
research in the medical and pharmaceutical sectors due to their 
extensive usage. To enhance cancer diagnostic and treatment criteria, 
novel bioactive compounds with increased efficacy are always needed. 
The study's main objective was to investigate the therapeutic potential 
of isolated terpene phytocompounds and terpene-based nanoemulsions
against BRCA1, TPX2, P53 and WWP1 gene expression in cancer and 
breast cancer indicators.  After being extracted from Catharanthus 
roseus, terpene chemicals were subjected to computational docking 
study.  Using molecular docking, ADMET analysis, and dynamic 
simulation techniques, the found terpene compound's binding 
capability and inhibitory effect to target breast cancer receptors such as 
progesterone receptor (PR) and human epidermal growth factor 
receptor 2 (HER2) were evaluated.  The findings showing the terpene 
from the Catharanthus roseus plant has potential benefits to prevent 
breast cancer inflammatory biomarkers, lower the amount of oxidative 
stress enzymes, and aid in downregulating the expression of genes 
involved in cancer proliferation are all supported by these data.